double stranded rna induced gene expression
| PAG Title | double stranded rna induced gene expression |
| PAG ID | WAG001242 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | One defense against viral infection is provided by PKR, double-stranded R activated protein kise. When PKR interacts with dsR found in cells during viral infection, PKR phosphorylates itself and cellular proteins including the translation factor elF2a and the transcription factor NF-kB. The repression of translation caused by phosphorylation of elF2a prevents cells from producing viral proteins and creating infectious viral particles. PKR phosphorylation of I-kB kise activates NF-kB to induce transcription of inflammatory factors and stimulate an immune response that impedes viral infection. The PKR kise is induced by interferon and some of the anti-viral activity of interferon may be mediated by PKR. Some viruses have evolved mechanisms to ictivate PKR to promote successful infection. Another substrate of PKR, the tumor suppressor p53, may be involved in potential PKR regulation of the cell cycle and apoptosis. |
| Species | Homo sapiens |
| nCoCo Score | 328 |
| Base PAG ID | WAG001242 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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